Anti-monocyte chemoattractant protein-1 gene therapy attenuates nephritis in MRL/lpr mice
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منابع مشابه
Anti-monocyte chemoattractant protein-1 gene therapy attenuates nephritis in MRL/lpr mice.
OBJECTIVE Monocyte chemoattractant protein-1 (MCP-1) is up-regulated and recruits and activates inflammatory cells in human diffuse proliferative lupus nephritis (DPLN) and in nephritis of lupus model MRL/lpr mice. The aim of this study was to examine whether anti-MCP-1 gene therapy inhibits the progression of nephritis in MRL/lpr mice. METHOD An NH(2)-terminal deletion mutant of the MCP-1 ge...
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BACKGROUND Monocyte chemoattractant protein 1 (MCP-1) is a member of the C-C chemokine family and exerts strong chemoattractant activity in monocytes, macrophages, and lymphocytes. Rat pancreatic fibrosis induced by dibutyltin dichloride (DBTC) is considered to be an appropriate chronic pancreatitis model histologically and enzymatically, as has demonstrated in a previous study. AIM We examin...
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ژورنال
عنوان ژورنال: Rheumatology
سال: 2004
ISSN: 1460-2172
DOI: 10.1093/rheumatology/keh277